![]() The reason for the delay was the fear of side effects based on the work of Lavoisier and Seguin who had suspected toxic effects of highly concentrated oxygen in 1789. Though John Priestly discovered oxygen as soon as 1775, the marginally effective compressed air therapy was only cautiously replaced by breathing of 100% oxygen under increased ambient pressure, thus initiating “hyperbaric oxygenation”. In 1662, Henshaw, a British physician first utilized hyperbaric therapy, placing patients in a steel container that was pressurized with air. Well-designed studies are needed to definitively assess its clinical value as an adjunctive treatment focusing on relevant outcome criteria such as wound healing time, complications, length of hospital stay, mortality and scar quality, while also defining optimal HBO dosage and timing. The few negative results are most likely due to peculiarities in the administration of HBO and possibly also to interactions when delivering the treatment to severely ill patients. Conclusions: HBO unquestionably has a positive impact on the pathophysiological mechanisms, and hence on the healing and course of burns. Authors of large clinical studies underscored the intricate measures required when administering HBO in severe burns. The application of HBO, however, concerning pressure, duration, frequency and number of treatment sessions, varied considerably. Secondary enlargement of burn was prevented, as microvascular perfusion could be preserved, and cells were kept viable. Except four investigators who found little or no beneficial action, all were able to demonstrate positive effects of HBO, most of them describing less edema, improved healing, less infection or bacterial growth and most recently, reduction of post-burn pain. ![]() Results: Forty-seven publications (32 animal experiments, four trials in human volunteers and 11 clinical studies) fulfilled the inclusion criteria. Materials and Methods: We did a retrospective analysis of the literature according to PRISMA-guidelines, from the very beginning of HBO for burns up to present, trying to elucidate the question why HBO is still sidelined in the treatment of burn injury. Despite many undisputedly positive and only a few controversial results on the efficacy of adjunctive HBO for burn injury, the method has not yet been established in clinical routine. Since the initiation of HBO for burns in 1965, abundant experimental and clinical work has been done. Count on us for advanced care that helps treat severe burns and prevent complications so you can heal.Background and Objectives: Hyperbaric oxygenation (HBO) denotes breathing of 100% oxygen under elevated ambient pressure. Our burn center care team treats more than 450 hospitalized patients yearly, and hundreds more receive treatment and go home the same day. It means you’ll get the highest level of care from the time of your injury through recovery and rehabilitation. ![]() Our Regional Burn Center meets the highest-quality criteria set by the American Burn Association (ABA) and American College of Surgeons (ACS) for a verified pediatric and adult burn center. We can respond to even the most complex medical issues with leading-edge treatments, advanced diagnostic and surgical techniques, and a comprehensive team approach to burn care. As San Diego County and Imperial County's only adult and pediatric burn center, we treat all kinds of burn injuries and wounds, including first-degree or superficial burns, second-degree and third-degree burns. Rely on UC San Diego Health Regional Burn Center for personalized burn care and treatment for people of all ages.įeel confident you or a loved one will receive the best possible care from our experienced team.
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